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DNA Damage, DNA Repair, Aging, and Neurodegeneration

Aging in mammals is accompanied by a progressive atrophy of tissues and organs, and stochastic damage accumulation to the macromolecules DNA, RNA, proteins, and lipids. The sequence of the human genome represents our genetic blueprint, and accumulating evidence suggests that loss of genomic maintena...

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Bibliographic Details
Published in:Cold Spring Harb Perspect Med
Main Authors: Maynard, Scott, Fang, Evandro Fei, Scheibye-Knudsen, Morten, Croteau, Deborah L., Bohr, Vilhelm A.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588127/
https://ncbi.nlm.nih.gov/pubmed/26385091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a025130
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