Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant.
Although insulin-like growth factor I (IGF-I) is a mitogenic growth factor, its role in tumorigenesis is unclear. We therefore transfected wild-type and truncated beta-subunit mutant (952STOP) human IGF-I receptor cDNAs into Rat-1 fibroblasts. Rat-1 transfectants expressed 2.5- to 7-fold increased I...
Furkejuvvon:
| Publikašuvnnas: | Proc Natl Acad Sci U S A |
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| Váldodahkkit: | , , , |
| Materiálatiipa: | Artigo |
| Giella: | Inglês |
| Almmustuhtton: |
National Academy of Sciences
1994
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| Fáttát: | |
| Liŋkkat: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43334/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8134369/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.6.2181 |
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