Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant.

Although insulin-like growth factor I (IGF-I) is a mitogenic growth factor, its role in tumorigenesis is unclear. We therefore transfected wild-type and truncated beta-subunit mutant (952STOP) human IGF-I receptor cDNAs into Rat-1 fibroblasts. Rat-1 transfectants expressed 2.5- to 7-fold increased I...

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Argitaratua izan da:	Proc Natl Acad Sci U S A
Egile Nagusiak:	Prager, D, Li, H L, Asa, S, Melmed, S
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	National Academy of Sciences 1994
Gaiak:	Research Article
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43334/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8134369/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.6.2181
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