The prion protein is critical for DNA repair and cell survival after genotoxic stress

The prion protein (PrP) is highly conserved and ubiquitously expressed, suggesting that it plays an important physiological function. However, despite decades of investigation, this role remains elusive. Here, by using animal and cellular models, we unveil a key role of PrP in the DNA damage respons...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Bravard, Anne, Auvré, Frédéric, Fantini, Damiano, Bernardino-Sgherri, Jacqueline, Sissoëff, Ludmilla, Daynac, Mathieu, Xu, Zhou, Etienne, Olivier, Dehen, Capucine, Comoy, Emmanuel, Boussin, François D., Tell, Gianluca, Deslys, Jean-Philippe, Radicella, J. Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333392/
https://ncbi.nlm.nih.gov/pubmed/25539913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1342
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