Considering the kinetics of mRNA synthesis in the analysis of the genome and epigenome reveals determinants of co-transcriptional splicing

When messenger RNA splicing occurs co-transcriptionally, the potential for kinetic control based on transcription dynamics is widely recognized. Indeed, perturbation studies have reported that when transcription kinetics are perturbed genetically or pharmacologically splice patterns may change. Howe...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Davis-Turak, Jeremy C., Allison, Karmel, Shokhirev, Maxim N., Ponomarenko, Petr, Tsimring, Lev S., Glass, Christopher K., Johnson, Tracy L., Hoffmann, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Computational Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333389/
https://ncbi.nlm.nih.gov/pubmed/25541195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1338
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