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RNA structure generates natural cooperativity between single-stranded RNA binding proteins targeting 5′ and 3′UTRs

In post-transcriptional regulation, an mRNA molecule is bound by many proteins and/or miRNAs to modulate its function. To enable combinatorial gene regulation, these binding partners of an RNA must communicate with each other, exhibiting cooperativity. Even in the absence of direct physical interact...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Lin, Yi-Hsuan, Bundschuh, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333377/
https://ncbi.nlm.nih.gov/pubmed/25550422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1320
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