A pharmacometric pulmonary model predicting the extent and rate of distribution from plasma to epithelial lining fluid and alveolar cells—using rifampicin as an example

PURPOSE: The purpose of the study was to develop a drug-unspecific approach to pharmacometric modeling for predicting the rate and extent of distribution from plasma to epithelial lining fluid (ELF) and alveolar cells (AC) for data emanating from studies involving bronchoalveolar lavage (BAL) sampli...

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Bibliographic Details
Published in:Eur J Clin Pharmacol
Main Authors: Clewe, Oskar, Goutelle, Sylvain, Conte, John E., Simonsson, Ulrika S. H.
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2015
Subjects:
Pharmacokinetics and Disposition
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333237/
https://ncbi.nlm.nih.gov/pubmed/25620089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-014-1798-3
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