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Switched-memory B cells remodel B cell receptors within secondary germinal centers
Effective vaccines induce high-affinity memory B cells and durable antibody responses through accelerated mechanisms of natural selection. Secondary changes in antibody repertoires after vaccine boosts suggest progressive B cell receptor (BCR) re-diversification, but underlying mechanisms remain unr...
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| Опубликовано в: : | Nat Immunol |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4333102/ https://ncbi.nlm.nih.gov/pubmed/25642821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3095 |
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