Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing

Cyclin-dependent kinase 9 (CDK9) and CDK12 have each been demonstrated to phosphorylate the RNA polymerase II C-terminal domain (CTD) at serine 2 of the heptad repeat, both in vitro and in vivo. CDK9, as part of P-TEFb and the super elongation complex (SEC), is by far the best characterized of CDK9,...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Liang, Kaiwei, Gao, Xin, Gilmore, Joshua M., Florens, Laurence, Washburn, Michael P., Smith, Edwin, Shilatifard, Ali
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333096/
https://ncbi.nlm.nih.gov/pubmed/25561469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01426-14
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