Interaction of Cyclin-Dependent Kinase 12/CrkRS with Cyclin K1 Is Required for the Phosphorylation of the C-Terminal Domain of RNA Polymerase II

CrkRS (Cdc2-related kinase, Arg/Ser), or cyclin-dependent kinase 12 (CKD12), is a serine/threonine kinase believed to coordinate transcription and RNA splicing. While CDK12/CrkRS complexes were known to phosphorylate the C-terminal domain (CTD) of RNA polymerase II (RNA Pol II), the cyclin regulatin...

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Bibliografische gegevens
Hoofdauteurs: Cheng, S.-W. Grace, Kuzyk, Michael A., Moradian, Annie, Ichu, Taka-Aki, Chang, Vicky C.-D., Tien, Jerry F., Vollett, Sarah E., Griffith, Malachi, Marra, Marco A., Morin, Gregg B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486194/
https://ncbi.nlm.nih.gov/pubmed/22988298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06267-11
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