Connexin 43 Channels are Essential for Normal Bone Structure and Osteocyte Viability

Connexin (Cx) 43 serves important roles in bone function and development. Targeted deletion of Cx43 in osteoblasts or osteocytes leads to increased osteocyte apoptosis, osteoclast recruitment, and reduced biomechanical properties. Cx43 forms both gap junction channels and hemichannels, which mediate...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Xu, Huiyun, Gu, Sumin, Riquelme, Manuel A., Burra, Sirisha, Callaway, Danielle, Cheng, Hongyun, Guda, Teja, Schmitz, James, Fajardo, Roberto J., Werner, Sherry L., Zhao, Hong, Shang, Peng, Johnson, Mark L., Bonewald, Lynda F., Jiang, Jean X.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333056/
https://ncbi.nlm.nih.gov/pubmed/25270829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2374
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