Genetic mutation of p53 and suppression of the miR-17~92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D signaling

Lung cancer is the leading cause of cancer-related fatalities. Recent success developing genotypically-targeted therapies, with potency only in well-defined subpopulations of tumors, suggests a path to improving patient survival. We utilized a library of oligonucleotide inhibitors to microRNAs, a cl...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Borkowski, Robert, Du, Liqin, Zhao, Zhenze, McMillan, Elizabeth, Kosti, Adam, Yang, Chin-Rang, Suraokar, Milind, Wistuba, Ignacio I., Gazdar, Adi F., Minna, John D., White, Michael A., Pertsemlidis, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333022/
https://ncbi.nlm.nih.gov/pubmed/25519225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1329
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