Targeting mitochondrial proline dehydrogenase with a suicide inhibitor to exploit synthetic lethal interactions with p53 upregulation and glutaminase inhibition

Proline dehydrogenase (PRODH) is a p53-inducible inner mitochondrial membrane flavoprotein linked to electron transport for anaplerotic glutamate and ATP production, most critical for cancer cell survival under microenvironmental stress conditions. Proposing that PRODH is a unique mitochondrial canc...

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Bibliografiske detaljer
Udgivet i:Mol Cancer Ther
Main Authors: Scott, Gary K., Yau, Christina, Becker, Beatrice C., Khateeb, Sana, Mahoney, Sophia, Jensen, Martin Borch, Hann, Byron, Cowen, Bryan J., Pegan, Scott D., Benz, Christopher C.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679736/
https://ncbi.nlm.nih.gov/pubmed/31189611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1323
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