Sorafenib Ameliorates Renal Fibrosis through Inhibition of TGF-β-Induced Epithelial-Mesenchymal Transition

OBJECTIVE: This study was to investigate whether sorafenib can inhibit the progression of renal fibrosis and to study the possible mechanisms of this effect. METHODS: Eight-week-old rats were subjected to unilateral ureteral obstruction (UUO) and were intragastrically administered sorafenib, while c...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jia, Lining, Ma, Xiaotao, Gui, Baosong, Ge, Heng, Wang, Li, Ou, Yan, Tian, Lifang, Chen, Zhao, Duan, Zhaoyang, Han, Jin, Fu, Rongguo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332653/
https://ncbi.nlm.nih.gov/pubmed/25679376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117757
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