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Deletion of AU-Rich Elements within the Bcl2 3′UTR Reduces Protein Expression and B Cell Survival In Vivo

Post-transcriptional mRNA regulation by RNA binding proteins (RBPs) associated with AU-rich elements (AREs) present in the 3′ untranslated region (3’UTR) of specific mRNAs modulates transcript stability and translation in eukaryotic cells. Here we have functionally characterised the importance of th...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Díaz-Muñoz, Manuel D., Bell, Sarah E., Turner, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332480/
https://ncbi.nlm.nih.gov/pubmed/25680182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116899
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