Functional and dysfunctional conformers of human neuroserpin characterized by optical spectroscopies and Molecular Dynamics

Neuroserpin (NS) is a serine protease inhibitor (SERPIN) involved in different neurological pathologies, including the Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB), related to the aberrant polymerization of NS mutants. Here we present an in vitro and in silico characterization o...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Noto, Rosina, Santangelo, Maria Grazia, Levantino, Matteo, Cupane, Antonio, Mangione, Maria Rosalia, Parisi, Daniele, Ricagno, Stefano, Bolognesi, Martino, Manno, Mauro, Martorana, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Pub. Co 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332418/
https://ncbi.nlm.nih.gov/pubmed/25450507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2014.10.002
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