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The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop
Neuroserpin (NS) is an inhibitory protein belonging to the serpin family and involved in several pathologies, including the dementia Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB), a genetic neurodegenerative disease caused by accumulation of NS polymers. Our Molecular Dynamics si...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4556959/ https://ncbi.nlm.nih.gov/pubmed/26329378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13666 |
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