The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop

Neuroserpin (NS) is an inhibitory protein belonging to the serpin family and involved in several pathologies, including the dementia Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB), a genetic neurodegenerative disease caused by accumulation of NS polymers. Our Molecular Dynamics si...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Noto, Rosina, Randazzo, Loredana, Raccosta, Samuele, Caccia, Sonia, Moriconi, Claudia, Miranda, Elena, Martorana, Vincenzo, Manno, Mauro
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556959/
https://ncbi.nlm.nih.gov/pubmed/26329378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13666
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