Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets

Defensins are antimicrobial peptides that contribute broadly to innate immunity, including protection of mucosal tissues. Human α-defensin (HD)6 is highly expressed by secretory Paneth cells of the small intestine. However, in contrast to the other defensins, it lacks appreciable bactericidal activi...

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Détails bibliographiques
Publié dans:Science
Auteurs principaux: Chu, Hiutung, Pazgier, Marzena, Jung, Grace, Nuccio, Sean-Paul, Castillo, Patricia A., de Jong, Maarten F., Winter, Maria G., Winter, Sebastian E., Wehkamp, Jan, Shen, Bo, Salzman, Nita H., Underwood, Mark A., Tsolis, Renee M., Young, Glenn M., Lu, Wuyuan, Lehrer, Robert I., Bäumler, Andreas J., Bevins, Charles L.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332406/
https://ncbi.nlm.nih.gov/pubmed/22722251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1218831
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