Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets

Defensins are antimicrobial peptides that contribute broadly to innate immunity, including protection of mucosal tissues. Human α-defensin (HD)6 is highly expressed by secretory Paneth cells of the small intestine. However, in contrast to the other defensins, it lacks appreciable bactericidal activi...

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Publicat a:Science
Autors principals: Chu, Hiutung, Pazgier, Marzena, Jung, Grace, Nuccio, Sean-Paul, Castillo, Patricia A., de Jong, Maarten F., Winter, Maria G., Winter, Sebastian E., Wehkamp, Jan, Shen, Bo, Salzman, Nita H., Underwood, Mark A., Tsolis, Renee M., Young, Glenn M., Lu, Wuyuan, Lehrer, Robert I., Bäumler, Andreas J., Bevins, Charles L.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332406/
https://ncbi.nlm.nih.gov/pubmed/22722251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1218831
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