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Negative feedback buffers effects of regulatory variants

Mechanisms conferring robustness against regulatory variants have been controversial. Previous studies suggested widespread buffering of RNA misexpression on protein levels during translation. We do not find evidence that translational buffering is common. Instead, we find extensive buffering at the...

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Bibliografische gegevens
Gepubliceerd in:Mol Syst Biol
Hoofdauteurs: Bader, Daniel M, Wilkening, Stefan, Lin, Gen, Tekkedil, Manu M, Dietrich, Kim, Steinmetz, Lars M, Gagneur, Julien
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BlackWell Publishing Ltd 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332157/
https://ncbi.nlm.nih.gov/pubmed/25634765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20145844
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