Negative feedback buffers effects of regulatory variants

Mechanisms conferring robustness against regulatory variants have been controversial. Previous studies suggested widespread buffering of RNA misexpression on protein levels during translation. We do not find evidence that translational buffering is common. Instead, we find extensive buffering at the...

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Publicat a:Mol Syst Biol
Autors principals: Bader, Daniel M, Wilkening, Stefan, Lin, Gen, Tekkedil, Manu M, Dietrich, Kim, Steinmetz, Lars M, Gagneur, Julien
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332157/
https://ncbi.nlm.nih.gov/pubmed/25634765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20145844
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