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Negative feedback buffers effects of regulatory variants

Mechanisms conferring robustness against regulatory variants have been controversial. Previous studies suggested widespread buffering of RNA misexpression on protein levels during translation. We do not find evidence that translational buffering is common. Instead, we find extensive buffering at the...

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Detalhes bibliográficos
Publicado no:Mol Syst Biol
Main Authors: Bader, Daniel M, Wilkening, Stefan, Lin, Gen, Tekkedil, Manu M, Dietrich, Kim, Steinmetz, Lars M, Gagneur, Julien
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332157/
https://ncbi.nlm.nih.gov/pubmed/25634765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20145844
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