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Inhibition of a DNA Polymerase from Bacillus subtilis by Hydroxyphenylazopyrimidines
The antimicrobial agent, 6-(p-hydroxyphenylazo)-uracil, specifically inhibits DNA polymerase III of Bacillus subtilis with a K(i) of less than 1 μM. The inhibition requires prior reduction of the drug, is reversible, and is competitive with dGTP. High amounts of dATP prevent inhibition by the closel...
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| Опубликовано в: : | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
1973
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433193/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4630611/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.70.1.103 |
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