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Inhibition of a DNA Polymerase from Bacillus subtilis by Hydroxyphenylazopyrimidines

The antimicrobial agent, 6-(p-hydroxyphenylazo)-uracil, specifically inhibits DNA polymerase III of Bacillus subtilis with a K(i) of less than 1 μM. The inhibition requires prior reduction of the drug, is reversible, and is competitive with dGTP. High amounts of dATP prevent inhibition by the closel...

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Bibliografiske detaljer
Main Authors: Gass, Kenneth B., Low, Robert L., Cozzarelli, Nicholas R.
Format: Artigo
Sprog:Inglês
Udgivet: 1973
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC433193/
https://ncbi.nlm.nih.gov/pubmed/4630611
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