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HZ08 Reverse P-Glycoprotein Mediated Multidrug Resistance In Vitro and In Vivo
BACKGROUND: Multidrug efflux transporter P-glycoprotein (P-gp) is highly expressed on membrane of tumor cells and is implicated in resistance to tumor chemotherapy. HZ08 is synthesized and studied in order to find a novel P-gp inhibitor. METHODS: MDCK-MDR1 monolayer transport, calcein-AM P-gp inhibi...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4331368/ https://ncbi.nlm.nih.gov/pubmed/25689592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116886 |
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