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HZ08 Reverse P-Glycoprotein Mediated Multidrug Resistance In Vitro and In Vivo

BACKGROUND: Multidrug efflux transporter P-glycoprotein (P-gp) is highly expressed on membrane of tumor cells and is implicated in resistance to tumor chemotherapy. HZ08 is synthesized and studied in order to find a novel P-gp inhibitor. METHODS: MDCK-MDR1 monolayer transport, calcein-AM P-gp inhibi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hu, Zheyi, Zhou, Zaigang, Hu, Yahui, Wu, Jinhui, Li, Yunman, Huang, Wenlong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331368/
https://ncbi.nlm.nih.gov/pubmed/25689592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116886
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