Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes

Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant patients and the leading viral cause of birth defects after congenital infection. The glycoprotein complexes gH/gL/gO and gH/gL/UL128/UL130/UL131A (Pentamer) are key targets of the human humoral response against H...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Ciferri, Claudio, Chandramouli, Sumana, Donnarumma, Danilo, Nikitin, Pavel A., Cianfrocco, Michael A., Gerrein, Rachel, Feire, Adam L., Barnett, Susan W., Lilja, Anders E., Rappuoli, Rino, Norais, Nathalie, Settembre, Ethan C., Carfi, Andrea
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330774/
https://ncbi.nlm.nih.gov/pubmed/25624487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424818112
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