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Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils

Expansion of myeloid cells associated with solid tumor development is a key contributor to neoplastic progression. Despite their clinical relevance, the mechanisms controlling myeloid cell production and activity in cancer remains poorly understood. Using a multistage mouse model of breast cancer, w...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Casbon, Amy-Jo, Reynaud, Damien, Park, Chanhyuk, Khuc, Emily, Gan, Dennis D., Schepers, Koen, Passegué, Emmanuelle, Werb, Zena
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330753/
https://ncbi.nlm.nih.gov/pubmed/25624500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424927112
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