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HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice
Bone metastasis involves dynamic interplay between tumor cells and the local stromal environment. In bones, local hypoxia and activation of the hypoxia-inducible factor (HIF)-1α in osteoblasts are essential to maintain skeletal homeostasis. However, the role of osteoblast-specific HIF signaling in c...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5798374/ https://ncbi.nlm.nih.gov/pubmed/29339479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718009115 |
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