HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice

Bone metastasis involves dynamic interplay between tumor cells and the local stromal environment. In bones, local hypoxia and activation of the hypoxia-inducible factor (HIF)-1α in osteoblasts are essential to maintain skeletal homeostasis. However, the role of osteoblast-specific HIF signaling in c...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Devignes, Claire-Sophie, Aslan, Yetki, Brenot, Audrey, Devillers, Audrey, Schepers, Koen, Fabre, Stéphanie, Chou, Jonathan, Casbon, Amy-Jo, Werb, Zena, Provot, Sylvain
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798374/
https://ncbi.nlm.nih.gov/pubmed/29339479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718009115
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