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Protein folding and binding can emerge as evolutionary spandrels through structural coupling

Binding interactions between proteins and other molecules mediate numerous cellular processes, including metabolism, signaling, and gene regulation. These interactions often evolve in response to changes in the protein’s chemical or physical environment (such as the addition of an antibiotic). Sever...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Manhart, Michael, Morozov, Alexandre V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330747/
https://ncbi.nlm.nih.gov/pubmed/25624494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415895112
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