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Protein folding and binding can emerge as evolutionary spandrels through structural coupling

Binding interactions between proteins and other molecules mediate numerous cellular processes, including metabolism, signaling, and gene regulation. These interactions often evolve in response to changes in the protein’s chemical or physical environment (such as the addition of an antibiotic). Sever...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Manhart, Michael, Morozov, Alexandre V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330747/
https://ncbi.nlm.nih.gov/pubmed/25624494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415895112
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