A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds

Here, with the aim of obtaining insight into the intriguing selectivity of G-quadruplex (G4) ligands toward cancer compared to normal cells, a genetically controlled system of progressive transformation in human BJ fibroblasts was analyzed. Among the different comparative evaluations, we found a pro...

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Publicat a:Nucleic Acids Res
Autors principals: Salvati, Erica, Rizzo, Angela, Iachettini, Sara, Zizza, Pasquale, Cingolani, Chiara, D'Angelo, Carmen, Porru, Manuela, Mondello, Chiara, Aiello, Aurora, Farsetti, Antonella, Gilson, Eric, Leonetti, Carlo, Biroccio, Annamaria
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Molecular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330372/
https://ncbi.nlm.nih.gov/pubmed/25618850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv006
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