Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.
p53-deficient mouse embryonic fibroblasts were used to establish a direct mechanism of tumor suppression by p53 involving the destruction of oncogene-expressing cells by apoptosis. The absence of p53 enhanced cell growth, appeared sufficient for immortalization, and allowed a single oncogene [adenov...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1994
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43302/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8134344/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.6.2026 |
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