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Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

p53-deficient mouse embryonic fibroblasts were used to establish a direct mechanism of tumor suppression by p53 involving the destruction of oncogene-expressing cells by apoptosis. The absence of p53 enhanced cell growth, appeared sufficient for immortalization, and allowed a single oncogene [adenov...

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Autors principals: Lowe, S W, Jacks, T, Housman, D E, Ruley, H E
Format: Artigo
Idioma:Inglês
Publicat: 1994
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC43302/
https://ncbi.nlm.nih.gov/pubmed/8134344
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