Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

p53-deficient mouse embryonic fibroblasts were used to establish a direct mechanism of tumor suppression by p53 involving the destruction of oncogene-expressing cells by apoptosis. The absence of p53 enhanced cell growth, appeared sufficient for immortalization, and allowed a single oncogene [adenov...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Lowe, S W, Jacks, T, Housman, D E, Ruley, H E
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1994
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43302/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8134344/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.6.2026
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