Liposome-based mucus-penetrating particles (MPP) for mucosal theranostics: Demonstration of diamagnetic chemical exchange saturation transfer (diaCEST) magnetic resonance imaging (MRI)

Mucus barriers lining mucosal epithelia reduce the effectiveness of nanocarrier-based mucosal drug delivery and imaging (“theranostics”). Here, we describe liposome-based mucus-penetrating particles (MPP) capable of loading hydrophilic agents, e.g., the diaCEST MRI contrast agent barbituric acid (BA...

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Veröffentlicht in:Nanomedicine
Hauptverfasser: Yu, Tao, Chan, Kannie W. Y., Anonuevo, Abraham, Song, Xiaolei, Schuster, Benjamin S., Chattopadhyay, Sumon, Xu, Qingguo, Oskolkov, Nikita, Patel, Himatkumar, Ensign, Laura M., van Zjil, Peter C. M., McMahon, Michael T., Hanes, Justin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330119/
https://ncbi.nlm.nih.gov/pubmed/25461289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2014.09.019
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