Targeting Metal-Aβ Aggregates with Bifunctional Radioligand [(11)C]L2-b and a Fluorine-18 Analogue [(18)F]FL2-b

[Image: see text] Interest in quantifying metal-Aβ species in vivo led to the synthesis and evaluation of [(11)C]L2-b and [(18)F]FL2-b as radiopharmaceuticals for studying the metallobiology of Alzheimer’s disease (AD) using positron emission tomography (PET) imaging. [(11)C]L2-b was synthesized in...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Cary, Brian P., Brooks, Allen F., Fawaz, Maria V., Shao, Xia, Desmond, Timothy J., Carpenter, Garrett M., Sherman, Phillip, Quesada, Carole A., Albin, Roger L., Scott, Peter J. H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329991/
https://ncbi.nlm.nih.gov/pubmed/25705326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500413d
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