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MULTI-PATHWAY MODEL ENABLES PREDICTION OF KINASE INHIBITOR CROSS-TALK EFFECTS ON MIGRATION OF HER2-OVEREXPRESSING MAMMARY EPITHELIAL CELLS
Small molecule kinase inhibitors often modulate signaling pathways other than the one targeted, whether by direct “off-target” effects or by indirect “pathway cross-talk” effects. The presence of either or both of these classes of complicating factors impedes the predictive understanding of kinase i...
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| Pubblicato in: | Mol Pharmacol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4329972/ https://ncbi.nlm.nih.gov/pubmed/18349105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.107.043794 |
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