TRIM29 suppresses TWIST1 and invasive breast cancer behavior

TRIM29 (ATDC) exhibits a contextual function in cancer, but appears to exert a tumor suppressor role in breast cancer. Here we show that TRIM29 is often silenced in primary breast tumors and cultured tumor cells as a result of aberrant gene hypermethylation. RNAi-mediated silencing of TRIM29 in brea...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Ai, Lingbao, Kim, Wan-Ju, Alpay, Merve, Tang, Ming, Pardo, Carolina E., Hatakeyama, Shigetsugu, May, W. Stratford, Kladde, Michael P., Heldermon, Coy D., Siegel, Erin M., Brown, Kevin D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329918/
https://ncbi.nlm.nih.gov/pubmed/24950909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3579
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