An Antagonist Mutant IL-15/Fc Promotes Transplant Tolerance

BACKGROUND: IL-15 is a proinflammatory and antiapoptotic T-cell growth factor that plays an important role in a variety of autoimmune disorders and transplant rejection. To inhibit IL-15 function and to target IL-15 receptor (IL-15R) bearing cells, we have generated a unique lytic antagonistic mutan...

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Publicat a:Transplantation
Autors principals: Zheng, Xin Xiao, Gao, Wei, Donskoy, Elina, Neuberg, Manfred, Ruediger, Manfred, Strom, Terry B., Moll, Thomas
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329733/
https://ncbi.nlm.nih.gov/pubmed/16421485
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