Effects of an Agonist IL-2/Fc Fusion Protein, A Mutant Antagonist IL-15Fc Fusion Protein and Sirolimus on Cardiac Allograft Survival in Non-Human Primates

BACKGROUND: To tilt the immunologic balance towards tolerance and away from rejection, nonhuman primate recipients of cardiac allografts were treated with IL-2/Fc, mutant antagonist type (m) IL-15/Fc and sirolimus. METHODS: Heterotopic heart transplants were performed on fully mismatched cynomolgus...

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Autori principali: Millington, Timothy, Koulmanda, Maria, Ng, Choo, Boskovic, Svjetlan, Nadazdin, Ognjenka M., Benichou, Gilles, Zheng, Xin Xiao, Strom, Terry B., Madsen, Joren C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731051/
https://ncbi.nlm.nih.gov/pubmed/22366291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.healun.2012.01.864
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