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Differential effects of Denileukin Diftitox IL-2 immunotoxin on NK and regulatory T cells in non-human primates
Denileukin Diftitox (DD), a fusion protein comprised of IL-2 and diphtheria toxin was initially expected to enhance anti-tumor immunity by selectively eliminating regulatory T cells (Tregs) displaying the high affinity IL-2R (α-β-γ trimers). While DD has been shown to deplete some Tregs in primates,...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3370077/ https://ncbi.nlm.nih.gov/pubmed/22586034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200656 |
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