Differential effects of Denileukin Diftitox IL-2 immunotoxin on NK and regulatory T cells in non-human primates

Denileukin Diftitox (DD), a fusion protein comprised of IL-2 and diphtheria toxin was initially expected to enhance anti-tumor immunity by selectively eliminating regulatory T cells (Tregs) displaying the high affinity IL-2R (α-β-γ trimers). While DD has been shown to deplete some Tregs in primates,...

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Autori principali: Yamada, Yohei, Aoyama, Akihiro, Tocco, Georges, Boskovic, Svjetlan, Nadazdin, Ognjenka, Alessandrini, Alessandro, Madsen, Joren C., Cosimi, A. Benedict, Benichou, Gilles, Kawai, Tatsuo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370077/
https://ncbi.nlm.nih.gov/pubmed/22586034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200656
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