Mutagenic and cytotoxic activity of benzol[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols.

The benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols (4-, 5-, 7-, 8-, 9-, and 10-hydroxybenzo[a]pyrene) have been tested for mutagenic and cytotoxic activity in bacteria and in a mammalian cell culture system. Benzo[a]pyrene 4,5-oxide (K-region) was highly mutagenic in tw...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Wood, A W, Goode, R L, Chang, R L, Levin, W, Conney, A H, Yagi, H, Dansette, P M, Jerina, D M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1975
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC432944/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1103140/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.72.8.3176
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