The NHLBI-Sponsored Consortium for preclinicAl assESsment of cARdioprotective Therapies (CAESAR): A New Paradigm for Rigorous, Accurate, and Reproducible Evaluation of Putative Infarct-Sparing Interventions in Mice, Rabbits, and Pigs

RATIONALE: Despite four decades of intense effort and substantial financial investment, the cardioprotection field has failed to deliver a single drug that effectively reduces myocardial infarct size in patients. A major reason is insufficient rigor and reproducibility in preclinical studies. OBJECT...

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Dettagli Bibliografici
Pubblicato in:Circ Res
Autori principali: Jones, Steven P., Tang, Xian-Liang, Guo, Yiru, Steenbergen, Charles, Lefer, David J., Kukreja, Rakesh C., Kong, Maiying, Li, Qianhong, Bhushan, Shashi, Zhu, Xiaoping, Du, Junjie, Nong, Yibing, Stowers, Heather L., Kondo, Kazuhisa, Hunt, Gregory N., Goodchild, Traci T., Orr, Adam, Chang, Carlos C., Ockaili, Ramzi, Salloum, Fadi N., Bolli, Roberto
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329104/
https://ncbi.nlm.nih.gov/pubmed/25499773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.305462
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