Actomyosin bundles serve as a tension sensor and a platform for ERK activation

Tensile forces generated by stress fibers drive signal transduction events at focal adhesions. Here, we report that stress fibers per se act as a platform for tension-induced activation of biochemical signals. The MAP kinase, ERK is activated on stress fibers in a myosin II-dependent manner. In myos...

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Bibliografiske detaljer
Udgivet i:EMBO Rep
Main Authors: Hirata, Hiroaki, Gupta, Mukund, Vedula, Sri Ram Krishna, Lim, Chwee Teck, Ladoux, Benoit, Sokabe, Masahiro
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2015
Fag:
Scientific Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4328752/
https://ncbi.nlm.nih.gov/pubmed/25550404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439140
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