Modulation of TNF-α mRNA stability by human antigen R and miR181s in sepsis-induced immunoparalysis

Immunoparalysis is an important pathological mechanism in sepsis. However, an effective small molecule therapy is lacking. Here, we show that ouabain, a Na(+),K(+)-ATPase ligand, can reverse immunoparalysis in vitro, in vivo, and in clinical samples. Notably, the effect of ouabain was critically dep...

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Bibliografske podrobnosti
izdano v:EMBO Mol Med
Main Authors: Dan, Cao, Jinjun, Bian, Zi-Chun, Hua, Lin, Ma, Wei, Chen, Xu, Zhang, Ri, Zhou, Shun, Cheng, Wen-Zhu, Sun, Qing-Cai, Jiao, Wu, Yin
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2015
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4328645/
https://ncbi.nlm.nih.gov/pubmed/25535255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404797
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