miR-346 Controls Release of TNF-α Protein and Stability of Its mRNA in Rheumatoid Arthritis via Tristetraprolin Stabilization

TNF-α is a major cytokine implicated in rheumatoid arthritis. Its expression is regulated both at the transcriptional and posttranscriptional levels and recent data demonstrated that miRNAs are implicated in TNF-α response in macrophages. LPS-activated FLS isolated from RA patients express TNF-α mRN...

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Detalhes bibliográficos
Main Authors: Semaan, Noha, Frenzel, Laurent, Alsaleh, Ghada, Suffert, Guillaume, Gottenberg, Jacques-Eric, Sibilia, Jean, Pfeffer, Sebastien, Wachsmann, Dominique
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096642/
https://ncbi.nlm.nih.gov/pubmed/21611196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019827
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