Kaolin-induced chronic hydrocephalus accelerates amyloid deposition and vascular disease in transgenic rats expressing high levels of human APP

BACKGROUND: Normal pressure hydrocephalus (NPH) is most common in the elderly and has a high co-morbidity with Alzheimer’s disease (AD) and cerebrovascular disease (CVD). To understand the relationship between NPH, AD and CVD, we investigated how chronic hydrocephalus impacts brain amyloid-beta pept...

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Bibliografiske detaljer
Udgivet i:Fluids Barriers CNS
Main Authors: Silverberg, Gerald D, Miller, Miles C, Pascale, Crissey L, Caralopoulos, Ilias N, Agca, Yuksel, Agca, Cansu, Stopa, Edward G
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4328504/
https://ncbi.nlm.nih.gov/pubmed/25685319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-8118-12-2
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