Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells

Mitochondrial glutaminase (GA) plays an essential role in cancer cell metabolism, contributing to biosynthesis, bioenergetics and redox balance. Humans contain several GA isozymes encoded by the GLS and GLS2 genes, but the specific roles of each in cancer metabolism are still unclear. In this study,...

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Udgivet i:J Mol Med (Berl)
Main Authors: Martín-Rufián, Mercedes, Nascimento-Gomes, Renata, Higuero, Ana, Crisma, Amanda R., Campos-Sandoval, José A., Gómez-García, María C., Cardona, Carolina, Cheng, Tzuling, Lobo, Carolina, Segura, Juan A., Alonso, Francisco J., Szeliga, Monika, Albrecht, Jan, Curi, Rui, Márquez, Javier, Colquhoun, Alison, DeBerardinis, Ralph J., Matés, José M.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4327995/
https://ncbi.nlm.nih.gov/pubmed/24276018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-013-1105-2
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