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Silencing of GLS and overexpression of GLS2 genes cooperate in decreasing the proliferation and viability of glioblastoma cells

Glutamine (Gln) metabolism, initiated by its degradation by glutaminases (GA), is elevated in neoplastic cells and tissues. In malignant glia-derived tumors, GA isoforms, KGA and GAC, coded by the GLS gene, are overexpressed, whereas the GLS2-coded GAB and LGA isoforms, are hardly detectable in ther...

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Autors principals: Szeliga, Monika, Bogacińska-Karaś, Małgorzata, Różycka, Aleksandra, Hilgier, Wojciech, Marquez, Javier, Albrecht, Jan
Format: Artigo
Idioma:Inglês
Publicat: Springer Netherlands 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967065/
https://ncbi.nlm.nih.gov/pubmed/24096582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13277-013-1247-4
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