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Modulating Inhibitors of Transthyretin Fibrillogenesis via Sulfation: Polychlorinated Biphenyl Sulfates as Models()

Small molecules that bind with high affinity to thyroxine (T(4)) binding sites on transthyretin (TTR) kinetically stabilize the protein’s tetrameric structure, thereby efficiently decreasing the rate of tetramer dissociation in TTR related amyloidoses. Current research efforts aim to optimize the am...

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Detalhes bibliográficos
Publicado no:Chem Biol Interact
Main Authors: Grimm, Fabian A., Lehmler, Hans-Joachim, He, Xianran, Robertson, Larry W., Duffel, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4327905/
https://ncbi.nlm.nih.gov/pubmed/25595224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2015.01.002
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